I provide an examination and comparison of modal theories for underwriting different non-modal theories of sets. I argue that there is a respect in which the `standard' modal theory for set construction---on which sets are formed via the successive individuation of powersets---raises a significant challenge for some recently proposed `countabilist' modal theories (i.e. ones that imply that every set is countable). I examine how the countabilist can respond to this issue via the use of regularity axioms and raise some questions (...) about this approach. I argue that by comparing them with the `standard' uncountabilist theory, a new approach that brings in arbitrariness rather than the strict controls of forcing is desirable. (shrink)

In this chapter, we argue for three theses: (1) we lack the power to form beliefs at will (i.e., directly); at very least, we lack the power to form at will beliefs of the kind that proponents of doxastic voluntarism have in mind; but (2) we possess a propensity to form beliefs for non-epistemic reasons; and (3) these propensities—once we come to know we have them—entail that we have obligations similar to those we would have were doxastic voluntarism true. Specifically, (...) we will argue that we have obligations to avoid triggering these propensities to form beliefs that are unwarranted or even immoral. (shrink)

Informal rigour is the process by which we come to understand particular mathematical structures and then manifest this rigour through axiomatisations. Structural relativity is the idea that the kinds of structures we isolate are dependent upon the logic we employ. We bring together these ideas by considering the level of informal rigour exhibited by our set-theoretic discourse, and argue that different foundational programmes should countenance different underlying logics (intermediate between first- and second-order) for formulating set theory. By bringing considerations of (...) perturbations in modal space to bear on the debate, we will suggest that a promising option for representing current set-theoretic thought is given by formulating set theory using quasi-weak second-order logic. These observations indicate that the usual division of structures into \particular (e.g. the natural number structure) and general (e.g. the group structure) is perhaps too coarse grained; we should also make a distinction between intentionally and unintentionally general structures. (shrink)

Sometimes people posit "beliefs" to explain mundane instrumental actions (e.g., Neil believes the switch is connected to the light, so he flipped the switch to illuminate the room). Sometimes people posit "beliefs" to explain group affiliation or identity (e.g., in order to belong to the Christian Reformed Church Neil must believe that God is triune). If we set aside the commonality of the word "belief," we can pose a crucial question: Is the cognitive attitude typically involved in the (...) first "light switch" sort of case the same as the cognitive attitude typically involved in the second "Trinity" sort of case? Or: Is mundanely believing the same cognitive relation as groupishly believing? In this essay, I argue that the answer is no. Mundane Beliefs play their instrumental roles well if they are true, and their manner of processing is accordingly sensitive to evidence. Groupish Beliefs play their identity-constituting roles well if they are distinctive, and their manners of processing accordingly allow for and often support distortions of evidence and truth. The manners of processing are thus so different that--despite the common word "belief"--philosophy of mind and epistemology would do well to recognize distinct cognitive attitudes. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume Studies Volume 31, Number 1, April 2005, pp. 123-144 Laws Not Men: Hume's Distinction between Barbarous and Civilized Government NEIL McARTHUR 1. Introduction Hume uses the adjectives "civilized" and "barbarous" in a variety of ways, and in a variety of contexts. He employs them to describe individuals, societies, historical eras, and forms of government. These various uses are closely related. Hume thinks that cultural and political development (...) are intimately connected, and are mutually dependent. Civilized government goes together with civilized society. A wise ruler cannot emerge before "refinements have taken place" in the society at large and "science [becomes] known in the world." At the same time, the policy of a monarch who is "ignorant and uninstructed... for ever prevents all improvements."1 This intimate connection, however, is not an identification. A civilized government is not simply that which produces, or results from, a civilized society. When discussing forms of government, Hume uses the terms "barbarous" and "civilized" consistently and somewhat narrowly, to describe governments that possess certain specific characteristics. It is striking that these characteristics are explicitly divorced from the abilities or characters of the rulers. While a nation requires wise and refined leadership to achieve its civilized status, Hume thinks it is a crucial feature of civilized government that, once established, it depends Neil McArthur is at the University of Manitoba, Winnipeg, Manitoba R3T 2M8, Canada, e-mail: [email protected] 124 Neil McArthur entirely on its institutional structure, and not on the talents or intentions of any individual or group. To understand Hume's distinction between these two kinds of government, it is useful to abstract away from his discussion of more general issues of cultural development, and to lay temporarily aside the causal question of what social and economic conditions are necessary to produce a civilized government. I propose to explain Hume's concepts of barbarous and civilized government just in terms of the institutional characteristics possessed by each. Hume's choice of adjectives is not, of course, accidental. The complex causal questions of how a civilized government comes about, and what is its relation to civilized society, are large and important ones. However, 1 do not propose to take them up here.2 The crucial feature dividing civilized and barbarous government is their relation to law. In his essay "Of Civil Liberty" Hume says: "It may now be affirmed of civilized monarchies, what was formerly said in praise of republics alone, that they are a government of Laws, not of Men."3 "Barbarous government" are thus "governments of men"—he also calls them governments "of will."4 Scholars of Hume's political theory have noted the importance of the rule of law in defining "civilized government. "5 However, they have not made clear precisely what Hume thinks precisely defines a "government of laws. " I submit that such a government must (for Hume) possess three characteristics. It must have: 1. A clear separation between the legislative and magisterial "powers" of the state; 2. A rigid subordination of the magisterial to the legislative power, such that the "discretion" of magistrates is restricted by "general laws"; 3. Self-sufficient laws and institutions, such that they are able to operate regardless of the intentions or abilities of individual rulers or officeholders. To this end, a government of laws must possess fixed rules governing the succession of officers, including (in a civilized monarchy) succession to the throne. Hume thinks specific governments may meet these criteria to varying degrees through time (with regression also possible). His use of the term "civilized government" nevertheless implies that it exists as a distinct, and achievable, ideal. An examination of Hume's theory of civilized government shows his understanding of the rule of law to be more subtle and complex than has previously been acknowledged. Hume moves beyond traditional Whig panegyrics on the rule of show to show how the law must operate if it is to protect people from oppression in the local theatres in which it is most acute. He articulates a theory of "civilized monarchy" that provides a middle path between republican and absolutist theories of government, and that is consistent his philosophy as a whole. Hume Studies Laws... (shrink)

Imagination contributes to human agency in ways that haven't been well understood. I argue here that pathways from imagistic imagining to emotional engagement support three important agential capacities: 1. bodily preparedness for potential events in one's nearby environment; 2. evaluation of potential future action; and 3. empathy-based moral appraisal. Importantly, however, the kind of pathway in question (I-C-E-C: imagining-categorization-emotion-conceptualization) also enables engagement with fiction. So human enchantment with fiction is a consequence of imaginative pathways that make us the kind of (...) agents we are. Finally, I use this approach to address imaginative resistance and the paradox of fiction. [The version archived here is a penultimate draft. Please email me at [email protected] to receive a pdf of the final in accordance with fair use.]. (shrink)

I raise three puzzles concerning self-deception: (i) a conceptual paradox, (ii) a dilemma about how to understand human cognitive evolution, and (iii) a tension between the fact of self-deception and Davidson’s interpretive view. I advance solutions to the first two and lay a groundwork for addressing the third. The capacity for self-deception, I argue, is a spandrel, in Gould’s and Lewontin’s sense, of other mental traits, i.e., a structural byproduct. The irony is that the mental traits of which self-deception is (...) a spandrel/byproduct are themselves rational. (shrink)

When someone says she believes that God exists, is she expressing the same kind of mental state as when she says she thinks that a lake bigger than Lake Michigan exists⎯i.e., does she refer to the same kind of cognitive attitude in both cases? Using evidence from linguistic corpora (Study 1) and behavioral experiments (Studies 2-4), the current work provides evidence that individuals typically use the word “believe” more in conjunction with statements about religious credences and “think” more in conjunction (...) with factual statements, pointing to two different understandings of claims made with these two terms. These patterns do not appear to reflect low-level differences based on the amount of consensus surrounding a particular claim, the extent to which the truth of a particular claim is known to the participant, or linguistic differences between religious and factual statements. We discuss implications of these findings for religious cognition (e.g., as supporting the theory that religious credences are qualitatively distinct from factual beliefs) as well as cognitive processes more broadly. Finally, we relate the present findings to prior theoretical work on differences between factual belief and religious credence. (shrink)

The study of biodiversity spans many disciplines and includes data pertaining to species distributions and abundances, genetic sequences, trait measurements, and ecological niches, complemented by information on collection and measurement protocols. A review of the current landscape of metadata standards and ontologies in biodiversity science suggests that existing standards such as the Darwin Core terminology are inadequate for describing biodiversity data in a semantically meaningful and computationally useful way. Existing ontologies, such as the Gene Ontology and others in the Open (...) Biological and Biomedical Ontologies (OBO) Foundry library, provide a semantic structure but lack many of the necessary terms to describe biodiversity data in all its dimensions. In this paper, we describe the motivation for and ongoing development of a new Biological Collections Ontology, the Environment Ontology, and the Population and Community Ontology. These ontologies share the aim of improving data aggregation and integration across the biodiversity domain and can be used to describe physical samples and sampling processes (for example, collection, extraction, and preservation techniques), as well as biodiversity observations that involve no physical sampling. Together they encompass studies of: 1) individual organisms, including voucher specimens from ecological studies and museum specimens, 2) bulk or environmental samples (e.g., gut contents, soil, water) that include DNA, other molecules, and potentially many organisms, especially microbes, and 3) survey-based ecological observations. We discuss how these ontologies can be applied to biodiversity use cases that span genetic, organismal, and ecosystem levels of organization. We argue that if adopted as a standard and rigorously applied and enriched by the biodiversity community, these ontologies would significantly reduce barriers to data discovery, integration, and exchange among biodiversity resources and researchers. (shrink)

Online hate speech has been a topic of public concern and research interest for some time. Initially the focus of this centred on the proliferation of online groups and websites promoting and distributing discriminatory content. Since the introduction of more interactive tools and platforms in the mid-2000s that enabled new and faster ways of disseminating content in a relatively anonymous fashion, concerns about online hate speech becoming a pervasive behavior have increased. Current research and analysis acknowledge the complex nature of (...) online hate, the mediating role of technology and the influence of other contextual factors (e.g. social or political events). However, despite the growing attention on the topic, New Zealand-based research looking at personal experiences and/or exposure to online hate is surprisingly absent. This study seeks to address this gap. It builds on existing international research on young people’s experiences to explore those of the adult New Zealand population based on a nationally representative sample. The research instrument used for this study was an online survey. (shrink)

In the 17th century the dissemination of philosophical ideas relied also on the critical summaries and reviews published by the journals. The focus of this paper is the reactions of two of these journals – the Journal de Trévoux, edited by the Jesuits of the Parisian Collège Louis Le Grand, and the Journal des Sçavans – to Condillac’s works. The Jesuit journal, under the direction of pére Berthier – probably himself the author of the reviews – had a precise (...) plan in presenting Condillac’s philosophy as an anti-empiricist and anti-materialist doctrine, sometime giving a misrepresentation of the author’s thought, which is also criticized on some points. The decision of the Journal de Trévoux to review the main works of Condillac is anyway worthy of attention, and probably betrays a certain interest toward the more up to date philosophical enquiry. The Journal des Sçavans was on the other hand more faithful in presenting Condillac’s works. (shrink)

DESENVOLVIMENTO EMBRIONÁRIO E DIFERENCIAÇÃO SEXUAL -/- E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede -/- 1.1 INTRODUÇÃO O sexo foi definido como a soma das diferenças morfológicas, fisiológicas e psicológicas que distinguem o macho da fêmea permitindo a reprodução sexual e assegurando a continuidade das espécies. Os processos de diferenciação sexual são realizados durante o desenvolvimento embrionário, onde ocorre a proliferação, diferenciação e maturação das células germinativas e primordiais, precursoras (...) de ovócitos e espermatozoides em fêmeas e machos, respectivamente. Assim, os embriões machos e fêmeas iniciam o seu desenvolvimento de forma semelhante, de modo que em ambos os sexos se estabelecem em estruturas idênticas a partir das quais se formarão os órgãos reprodutores correspondentes a cada sexo. O conhecimento da origem e do desenvolvimento do aparelho genital é indispensável para entender sua função e as alterações que produzem infertilidade ou esterilidade. 1.2 DETERMINAÇÃO DO SEXO CROMOSSÔMICO Nos mamíferos, o sexo cromossômico é determinado no momento da fertilização, quando um óvulo, que contém um cromossomo X, é fecundado por um espermatozoide portador de um cromossomo X ou um cromossomo Y. No primeiro caso, o complemento cromossômico seria XX, o que originaria uma fêmea (sexo homogamético), e no segundo daria como resultado um macho com a fórmula cromossômica XY (sexo heterogâmico). 1.3 A GÔNADA INDIFERENCIADA A primeira manifestação das gônadas se aprecia no embrião em forma de um par de eminências longitudinais chamadas cristas ou dobras gonodais, situadas em ambos os lados da linha média entre os mesonefros (rins em desenvolvimento) e do mesentério dorsal. Nos embriões dos mamíferos, as células germinativas primordiais (CGP) manifestam-se em estágios precoces do desenvolvimento, podendo ser detectadas pela primeira vez na metade da gastrulação. As CGP são células grandes, de citoplasma claro e núcleo grande e redondo, localizadas na parede do saco vitelino, perto do alantoide. Essas células possuem grande capacidade de proliferação e vão migrar desde o endoderma do intestino e o epitélio do saco vitelino, através do mesentério, até as cristas gonodais. Isso ocorre por volta do 26° dia da gestação no bovino. Sua migração realiza-se graças aos movimentos de translocação passiva e deslocamento ameboide ativo. Desconhece-se o mecanismo pelo qual estas células são dirigidas para as cristas gonodais, porém foram estudadas algumas moléculas que se expressam durante sua migração e que poderiam desempenhar um papel importante na diferenciação deste tipo celular. A fosfatase alcalina é uma enzima que tem sido usada como marcador de CGP para determinar a sua origem e migração. Num estudo recente, foi inserido um marcador fluorescente que se exprime unicamente nas células germinativas primordiais de embriões transgênicos, e utilizando este marcador e a fosfatase alcalina determinou-se a origem e o padrão de migração destas células. O primeiro sinal de diferenciação das células germinativas primordiais é a expressão de fosfatase alcalina, e esta apareceu pela primeira vez na parte mais posterior da linha primitiva. No sétimo dia de desenvolvimento no embrião do camundongo, o endoderma visceral (AF+) é substituído pelo endoderma definitivo (AF-) originado na parte anterior da linha primitiva. O fator de transcrição Oct-4 é expresso nas CGP de ambos os sexos, pelo que acredita-se estar envolvido na mantença a totipotêncialidade das células. O receptor tirosina quinase, cujo ligante é o fator de Steel, é outra das moléculas que expressam as CGP. Tem sido demonstrado que este receptor possui um papel muito importante na sobrevivência deste tipo celular. Existem outros fatores que promovem a sobrevivência e/ou proliferação de CGP in vitro. Em experiências realizadas com o fator de transformação beta I (TGFβ-I), observou-se que este tem um efeito negativo sobre a proliferação das CGP. Outra atividade que tem sido postulada a este fator é o de um agente quimioatraente que possivelmente possa direcionar a migração destas células para a gônada. a) Um formado pelas células germinativas primordiais (precursoras dos gametas masculinos ou femininos), rodeadas de células somáticas das quais posteriormente se derivarão as células de Sertoli no macho e as células da granulosa na fêmea. b) O tecido que formará o estroma da gônada: tecido conjuntivo, vasos sanguíneos e as células intersticiais com atividade esteroidogênica (células de Leydig no testículo e a teca interna do ovário). As células somáticas do primórdio gonodal originam-se do mesoderma. Inicialmente são de três tipos: mesenquimáticas, mesoteliais e endoteliais. As células mesenquimáticas e mesoteliais iniciam grande atividade proliferativa ao chegar as CGP. Observa-se então uma condensação de células de origem mesotelial e mesenquimatoso que forma um agregado compacto denominado "blastema gonodal". A partir deste primórdio embrionário, diferenciam-se dois tecidos gonodais: os cordões sexuais e o estroma. Os cordões sexuais são arranjos epiteliais que se encontram delimitados por uma folha basal, e dentro deles encontramos as CGP. Por sua vez, no estroma encontram-se células do tipo mesenquimático e vasos sanguíneos. Neste momento, as gônadas são indiferenciadas e bipotencialmente sexuais, sendo impossível diferenciar, morfologicamente, uma gônada masculina de uma feminina, mas no caso dos machos genéticos já existe uma diferenciação da gônada a nível molecular. Nesta fase já se encontram presentes as estruturas das quais se desenvolvem os dutos mesonéfricos ou de Wolff precursores do aparelho genital masculino e os dutos paramesonéfricos ou de Müller que darão origem ao aparelho reprodutor feminino. Há uma série de fatores envolvidos no desenvolvimento precoce da gônada, entre os quais o fator esteroidogênico I (SFI: Steroidogenic fator l), que é um membro da subfamília de receptores nucleares, receptores órfãos. Este fator de transcrição tem um local de ligação ao DNA composto por dois dedos-de-Zinc. O SFI foi identificado como um ativador de genes envolvidos na biossíntese de esteroides em diferentes células. O SFI está presente durante o desenvolvimento embrionário em regiões associadas com funções endócrinas como gônadas, adrenais, pituitárias e hipotálamos. Os animais homozigotos para o gene SFI defeituoso, necessitam de gônadas e adrenais e têm a função gonadotrófica alterada. Os ratos sem SFI carecem de gonadotrofos e têm um desenvolvimento anormal do núcleo ventro-medial do hipotálamo; em particular as gônadas deixam de se desenvolver entre os dias 11 a 15 e degeneram-se por apoptose. No entanto, a crista genital forma-se e é colonizada pelas células germinativas, o que indica que estas continuam a receber o sinal adequado para a sua migração. Portanto, o SFI não está envolvido no desenvolvimento precoce da gônada e do sistema urogenital, mas parece estar envolvido na manutenção do crescimento das células somáticas presentes na gônada indiferenciada. O gene associado ao tumor de Wilms (WTI: Wilm's tumor Associated) está envolvido no desenvolvimento da gônada e do rim. Durante o desenvolvimento embrionário, WTI se expressa em todo o mesoderma intermediário e posteriormente na gônada indiferenciada, bem como no rim em formação. WTI regula o sinal indutivo do mesênquima para o epitélio celômico dos mesonefros. Se este for o caso, então WTI é responsável pelo crescimento da crista genital ao dirigir a entrada do epitélio celômico. Dado que estas células darão origem às células de Sertoli, a carência de WTI pode causar o desenvolvimento de embriões XY como fêmeas simplesmente porque não se formam as células de Sertoli. Em geral, todos os genes importantes na diferenciação do mesoderma intermediário e do sistema urogenital intervêm no desenvolvimento da gônada precoce. 1.4 DIFERENCIAÇÃO GONODAL O desenvolvimento das gônadas e ductos genitais descritos até o momento, é o mesmo para ambos os sexos. Igualmente, os genes descritos, que estão envolvidos no desenvolvimento das gônadas, ductos genitais e migração das células germinativas, afetam igualmente os embriões com genótipo XX ou XY. A gônada primitiva consiste anatomicamente de uma medula (interna) e uma crosta (externa), e de acordo com o local onde ocorre a colonização das células germinativas, diferenciara em testículo ou um ovário, respectivamente. Nos mamíferos, a primeira manifestação estrutural de diferenciação sexual é detectada na gônada dos machos, onde as células germinativas estão localizadas na medula. A diferenciação do testículo inicia-se quando os cordões sexuais se separam do epitélio celômico como consequência dos arranjos produzidos por uma invasão do mesênquima e vasos sanguíneos que provoca a compactação dos cordões, agora denominados cordões testiculares. As células que rodeiam os cordões se achatam e formam as células mioides, que são responsáveis pela formação das membranas basais. As células do epitélio interno, ou seja, as células de Sertoli, têm duas funções principais: o suporte das CGP e a síntese da hormona antimulleriana, responsável pela regressão dos ductos de Müller e secretada durante o período de diferenciação sexual. As células do estroma que rodeiam os cordões testiculares diferenciam-se para formar vários tipos de células: células mioides, fibroblastos, endotélio e células de Leydig, que são as mais importantes pela sua atividade endócrina. Posteriormente, os cordões testiculares dão origem aos túbulos seminíferos, que contêm o epitélio que produzirá os espermatozoides ao chegar à puberdade. Na fêmea, durante os estágios iniciais de diferenciação gonodal, não se observam mudanças em relação à gônada indiferenciada, só pode-se observar um certo crescimento devido à proliferação de células somáticas e germinativas. As células germinativas iniciam um período de proliferação, que termina com o início da meiose. Iniciada a meiose, dá-se o processo de foliculogênese; neste momento os cordões epiteliais se fragmentam, de tal maneira que cada ovócito fica rodeado de células epiteliais cobertas por uma folha basal fina (figura 1). Para que a gônada primitiva se desenvolva em testículo é indispensável a presença do cromossoma Y, independentemente do número de cromossomas X que contenha o genoma de um indivíduo. O gene determinante do testículo encontra-se localizado no cromossoma Y, denominado sry em ratos e SRY em humanos. O gene sry se expressa durante o desenvolvimento embrionário na crista genital de embriões de camundongos. A expressão é detectável no dia 10,5, pouco depois do aparecimento das cristas genitais, atinge o seu máximo durante o dia 11,5 e mantém-se até pouco depois de ocorrerem os primeiros sinais morfológicos de diferenciação testicular no dia 12,5. Este padrão de expressão é compatível com a teoria de que sry atua induzindo a ativação dos genes (figura 2) que conduzem ao desenvolvimento testicular, sem que exista a necessidade da expressão contínua de sry para manter a diferenciação do testículo após o dia 12,5. Como mencionado anteriormente, a gônada primitiva é composta por vários tipos de células. No entanto, as células germinativas primordiais não são o local de expressão do sry, já que os embriões que necessitam de células germinativas mantêm a expressão de sry e desenvolvem o sexo gonodal normalmente. As células somáticas na gônada em desenvolvimento incluem também as células de suporte. Sabe-se que é nestas células que o sry é expresso para que se diferenciem em células de Sertoli, e a expressão transitória de sry indica que deve ativar a outros genes para a manutenção das células de Sertoli. Uma vez diferenciadas as células de Sertoli, elas se encarregarão da diferenciação do resto das células na gônada. -/- Figura 1: Representação da diferenciação dos órgãos genitais internos. Adaptado de BRONSON, 1989. Figura 2: Cascada de genes envolvidos na diferenciação sexual, adaptado de KOOPMAN, 1999. O fator sry é necessário para a diferenciação do testículo. Embora não se conheçam os genes que provavelmente regulam esse gene, estudos realizados em camundongos demonstram que este gene parece coordenar-se com certos genes autossômicos. Entre estes genes autossômicos, o sox9, que é produzido pelas células de Sertoli uma vez que são estimuladas por sry, de modo que sox9 é um dos genes relacionados estruturalmente com sry. O Sox9 funciona como um fator de transcrição, mas não se sabe se a proteína tem qualquer outra função estrutural; este gene exprime-se abundantemente nos condrócitos e está relacionado com defeitos do aparelho ósseo chamados displasia campomélica. Curiosamente, os pacientes XY com esta condição sofrem frequentemente de reversão do sexo. O Sox9 é um dos poucos genes, além do SRY, do qual as mutações demonstraram interferir com a determinação sexual masculina. No entanto, apenas 75% dos pacientes com anomalias esqueléticas de tipo displasia campomélica têm reversão sexual e não foram encontrados casos de reversão sexual devido a um defeito de Sox9 que não seja acompanhado de defeitos esqueléticos. Isso indica que o Sox9 é apenas um membro da rede de genes que são ativados para determinar a diferenciação sexual, enquanto a rota que rege a condrogênese é mais sensível a perturbações deste. O momento em que se detecta a expressão do gene Sox9 (11dpc em ratos) coincide com a máxima expressão de sry, o que poderia indicar a possibilidade de que sry regule positivamente a Sox9. De fato, na região do promotor de Sox9 há um local de união ao que potencialmente se pode unir o sry. A expressão de Sox9 durante a diferenciação sexual sugere um papel abaixo de sry na diferenciação das células de Sertoli. O cromossoma X também é importante na diferenciação gonodal. O gene DAX-I foi isolado do lócus DSS (Dosage sensitive sex reversal) do cromossoma X. DAX-I é parte da cascata de determinação sexual, mas não é necessário para a formação do testículo. DAX-I é um membro dos receptores nucleares conhecidos como receptores órfãos. Este gene demonstrou ser um poderoso repressor da transcrição de SFI e de vários genes. Os padrões de expressão de DAX-I são complementares daqueles de SFI, ambos expressos nas cristas genitais. Em resumo, dada a evidência exposta, desenvolveu-se a hipótese de que DAX-I é um antagonista de sry; esse antagonismo é dependente dos níveis relativos de DAX-I e sry e de um limiar que varia de espécie para espécie. A DAX-I foi classificada como o gene antitestículo. Na fêmea (cariótipo XX) é importante que ocorra a inativação de um dos cromossomas sexuais X para que se mantenha o equilíbrio genético ao igualar o conteúdo de DNA dos cromossomas. Esse cromossoma inativado constitui o chamado corpúsculo de Barr. No entanto, para que a meiose se realize, é necessário dos dois cromossomas X ativos nos ovócitos para assegurar a diferenciação ovárica e a fertilidade. 1.5 DIFERENCIAÇÃO DOS DUCTOS SEXUAIS O embrião possui, além das gônadas indiferenciadas, dois sistemas de ductos: os de potencialidade masculina denominam-se ductos de Wolff ou mesonéfricos, e os de potencialidade feminina se chamam ductos de Müller ou paramesonéfricos (figura 1). Se a diferenciação gonodal levou à formação de um testículo, a partir do ducto mesonéfrico ou de Wolff se desenvolverão os ductos eferentes, o epidídimo, os ductos deferentes e as vesículas seminais. As hormonas importantes no desenvolvimento do aparelho genital masculino são a testosterona, produzida pelas células de Leydig, e sua forma 5α reduzida, a 5α di-hidrotestosterona. Acredita-se que a testosterona é responsável pela virilização dos ductos de Wolff, e a di-hidrotestosterona dos órgãos genitais externos. No macho, os canais de Müller atrofiam-se devido à ação de uma hormona fetal de origem testicular denominada hormona inibidora das estruturas de Müller (HIM) ou hormona antimulleriana. Este processo começa assim que os cordões espermáticos se formam e se diferenciam as células de Sertoli. A existência de HIM foi proposta baseada em estudos realizados em bezerras freemartin, devido à existência de uma hormona responsável pela atresia dos ductos de Müller que na fêmea dá origem ao útero e aos ovidutos. Essa hormona provoca a involução do aparelho genital do bovino nas gestações gemelares nas quais os produtos de diferente sexo têm comunicação sanguínea por ter ocorrido a anastomose dos vasos de ambas as placentas (figura 3). A HIM é uma glicoproteína pertencente à subfamília de TGFβ, é expressa pelas células que darão origem às células de Sertoli e é um dos primeiros marcadores de diferenciação nestas células. A HIM é secretada na vida adulta pelas células de Sertoli no testículo e por células da granulosa no ovário. No rato a HIM é expressa-se no 12° dia em um teste padrão que segue muito de perto o aumento na expressão de sry. No macho, esta secreção de HIM continua durante a vida fetal e adulta, contudo os níveis de HIM declinam na puberdade devido a um aumento na secreção de testosterona. Vários fatores intervêm na regulação do gene de HIM, incluindo os acima descritos SFI e Sox9. O gene HIM contém segmentos de DNA que são conservados em várias espécies de vertebrados. Existe um nexo de ligação para SFI, que ativa a transcrição de HIM. A mutação no local de ligação de SFI resulta em reversão do sexo em indivíduos XY incluindo genitais femininos normais, presença de um útero formado enfatizando a importância de SFI na determinação sexual e na expressão de HIM. Embora SFI seja um bom candidato como regulador de HIM, é expresso em outras células, como as de Leydig e adrenais, que não expressam HIM. Em contrapartida, Sox9 é expresso unicamente nas células de Sertoli que são as produtoras de HIM. O gene HIM também tem um nexo de ligação para Sox9. Além disso, Sox9 pode atuar sinergicamente com SFI para promover a secreção de HIM. Ao contrário destes dois fatores de transcrição, DAX-I antagoniza a ação de Sox9 e provavelmente SFI sobre o promotor de HIM. Assim, para que as células de Sertoli secretem HIM, a transcrição de DAX-I deve diminuir. Figura 3: Representação da diferenciação dos órgãos genitais externos. Adaptado de BRONSON, 1989. Os ductos de Wolff tornam-se o sistema de ejaculação do macho. A porção mais próxima dos testículos dá origem ao epidídimo, a parte central ao ducto deferente e a porção mais distal às vesículas seminais. A próstata e a parte membranosa da uretra do macho desenvolvem-se a partir da porção pélvica do seio urogenital. A virilização e diferenciação dos ductos de Wolff dependem da produção de testosterona pelo testículo. Quanto aos órgãos genitais externos do macho, o tubérculo genital é ampliado e as dobras uretrais se fundem para formar a uretra peniana. A fusão das dobras uretrais aproxima os tubérculos genitais para formar o escroto (figura 4). Figura 4: Diferenciação do aparelho genital da fêmea e do macho. Adaptado de KOOPMAN, 1989. A diferenciação dos órgãos genitais da fêmea ocorre de forma passiva, já que a ausência de testículos e por isso da hormona inibidora dos ductos de Müller (HIM), assim como dos andrógenos virilizantes, favorece o desenvolvimento dos ductos de Müller, enquanto os de Wolff sofrem atrofia. A porção cefálica dos ductos de Müller dá origem aos ovidutos, que na sua terminação caudal se fundem com o útero. O contato dos ductos de Müller com o seio urogenital induz uma intensa proliferação celular que resulta na formação da área uterovaginal localizado entre o seio urogenital e os ductos de Müller. As células do prato uterovaginal proliferam e aumentam a distância entre as duas estruturas criando o espaço que formará a vagina quando o prato é canalizado e forma um lúmen. Em contraste com o que ocorre no macho, na fêmea a maior parte do seio urogenital se mantém exposta na superfície da abertura onde desembocam a vagina e a uretra. O tubérculo urogenital da fêmea tem um crescimento limitado e forma o clitóris. A sequência de passos da diferenciação sexual do aparelho genital é resumida na tabela 1. Tabela 1: Destino em desenvolvimento dos rudimentos sexuais dos fetos macho e fêmea dos mamíferos -/- Rudimento sexual Macho Fêmea Gônada Testículo Ovário Ductos de Müller (Paramesonéfricos) Vestígios Útero, parte da vagina, ovidutos Ductos de Wolff (Mesonéfricos) Ductos eferentes deferentes, epidídimo, vesículas seminais Vestígios Seio urogenital Uretra, próstata, glândulas bulbouretrais Parte da vagina, uretra, vestíbulo, glândulas vestibulares Tubérculo genital Pênis Clitóris Pregas vestibulares Escroto Lábios vulvares Fonte: HAFEZ, 2004. 1.6 DIFERENCIAÇÃO SEXUAL DO HIPOTÁLAMO Os processos de diferenciação sexual não se limitam apenas às células somáticas do organismo do feto, mas incluem também os centros nervosos superiores do cérebro. Assim, da mesma maneira que a gônada e os ductos sexuais se desenvolvem para o tipo feminino ou masculino, propôs-se que o cérebro pode ser "masculinizado" ou permanecer "Feminizado". A diferenciação do hipotálamo vai depender do ambiente esteroidal do neonato e ocorre na fase perinatal. Estes eventos serão de grande transcendência na vida reprodutiva do indivíduo. Tanto a fêmea como o macho nascem com a capacidade de secreção de gonadotropinas de acordo com um padrão cíclico; contudo, no macho, a exposição do hipotálamo à ação dos andrógenos testiculares durante os primeiros dias da vida extrauterina provoca a masculinização, com o qual o hipotálamo do macho é programado para que a secreção de gonadotropinas se realize a um ritmo relativamente constante por parte da hipófise (secreção tônica). Na fêmea, tanto a secreção tônica como a cíclica se conservam. No entanto, observou-se que a injeção de testosterona ou o transplante de testículo na rata fêmea durante os primeiros dias de vida, suprime a sua futura atividade estral (secreção cíclica). Por outro lado, se os ovários forem transplantados para o rato macho normal castrado na idade adulta, o animal não desenvolve qualquer atividade cíclica, mas se os machos transplantados forem castrados ao nascer, o ovário é capaz de efetuar mudanças cíclicas e ovulações. Isto foi demonstrado em roedores, mas não em animais domésticos ou na espécie humana. Portanto, o padrão de secreção de gonadotropinas, seja cíclico ou tônico, não depende da hipófise, mas do hipotálamo e sua correta diferenciação. 1.7 CONCLUSÕES A maioria dos conhecimentos no campo da biologia do desenvolvimento e, muito especificamente, dos processos de diferenciação sexual têm sido originados de estudos relacionados com desordens congênitas, que na sua maioria devem-se a defeitos de genes específicos. A análise detalhada destas desordens permitiu entender alguns mecanismos endócrinos, moleculares e genéticos envolvidos na diferenciação sexual. A identificação do gene sry como determinante do testículo foi uma contribuição crucial e abriu as portas à compreensão dos mecanismos moleculares e celulares relacionados com o desenvolvimento do testículo. Se este gene não estiver presente, é criado um programa genético alternativo para levar a cabo a diferenciação gonodal para o ovário. Finalmente, devemos ter presente que é necessária uma correlação entre mudanças morfológicas e expressão de genes durante o desenvolvimento para entender os mecanismos relacionados com a diferenciação. -/- Apoio -/- Realização -/- REFERÊNCIAS BIBLIOGRÁFICAS ANDERSON, Robert et al. The onset of germ cell migration in the mouse embryo. Mechanisms of development, v. 91, n. 1-2, p. 61-68, 2000. AUSTIN, Colin Russell; SHORT, R. V. Reproduction in Mammals: Volume 1, Germ Cells and Fertilization. Londres: Cambridge University Press, 1972. BRONSON, Franklin H. Mammalian reproductive biology. Chicago: University of Chicago Press, 1989. BUEHR, Mia. The primordial germ cells of mammals: some current perspectives. Experimental cell research, v. 232, n. 2, p. 194-207, 1997. BYSKOV, Anne G. Differentiation of mammalian embryonic gonad. Physiological reviews, v. 66, n. 1, p. 71-117, 1986. CAPEL, Blanche et al. Migration of mesonephric cells into the mammalian gonad depends on Sry. Mechanisms of development, v. 84, n. 1-2, p. 127-131, 1999. CAPEL, Blanche. The battle of the sexes. Mechanisms of development, v. 92, n. 1, p. 89-103, 2000. DERIVAUX, Jules; BARNABÉ, Renato Campanarut. Reprodução dos animais domésticos. Zaragoza: Acribia, 1980. DOMENICE, Sorahia et al. Aspectos moleculares da determinação e diferenciação sexual. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 46, n. 4, p. 433-443, 2002. DONAHOE, Patricia K. et al. Mullerian inhibiting substance activity in bovine fetal, newborn and prepubertal testes. Biology of reproduction, v. 16, n. 2, p. 238-243, 1977. HAFEZ, Elsayed Saad Eldin; HAFEZ, B. Reprodução animal. São Paulo: Manole, 2004. HANLEY, Neil A. et al. Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Molecular and cellular endocrinology, v. 163, n. 1-2, p. 27-32, 2000. HIORT, Olaf; PAUL-MARTIN, H. The molecular basis of male sexual differentiation. European journal of endocrinology, v. 142, n. 2, p. 101-110, 2000. HOLY, Lubos; MARTÍNEZ JÚSTIZ, G. Colab. Biología de la reproducción bovina. Havana: Revolucionária, 1975. JOSSO, Nathalie et al. The role of anti-Müllerian hormone in gonadal development. Molecular and cellular endocrinology, v. 145, n. 1-2, p. 3-7, 1998. JOST, Alfred et al. Studies on sex differentiation in mammals. In: Proceedings of the 1972 Laurentian Hormone Conference. Londres: Academic Press, 1973. p. 1-41. KNOBIL, Ernst. Knobil and Neill's physiology of reproduction. EUA: Gulf Professional Publishing, 2006. KOFMAN ALFARO, S.; MERCHANT LARIOS, H.; PEREZ PALACIOS, G. Diferenciacion sexual. I. Bases biologicas del dimorfismo sexual. Rev. invest. clín, p. 349-59, 1982. KOOPMAN, Peter. Sry and Sox9: mammalian testis-determining genes. Cellular and Molecular Life Sciences CMLS, v. 55, n. 6-7, p. 839-856, 1999. MCDONALD, L. E. Veterinary endocrinology. Lea & Febiger, Philadelphia, Pa, 1969. MEIZEL, S.; JOHNSON, M. H. Development in mammals. MH Johnson, Ed, v. 3, p. 1-64, 1978. MELLO, Maricilda Palandi de; ASSUMPÇÃO, Juliana de G.; HACKEL, Christine. Genes envolvidos na determinação e diferenciação do sexo. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 49, n. 1, p. 14-25, 2005. -/- REFERÊNCIAS BIBLIOGRÁFICAS MERCHANT-LARIOS, H. Ovarian differentiation. The Vertebrate Ovary, p. 47-81, 1978. MIES FILHO, Antonio. Reprodução dos animais. Porto Alegre: Sulina, 1987. NEF, Serge; PARADA, Luis F. Hormones in male sexual development. Genes & Development, v. 14, n. 24, p. 3075-3086, 2000. PARKER, Keith L.; SCHEDL, Andreas; SCHIMMER, Bernard P. Gene interactions in gonadal development. Annual review of physiology, v. 61, n. 1, p. 417-433, 1999. SWAIN, Amanda; LOVELL-BADGE, Robin. Mammalian sex determination: a molecular drama. Genes & development, v. 13, n. 7, p. 755-767, 1999. WILHELM, Dagmar; PALMER, Stephen; KOOPMAN, Peter. Sex determination and gonadal development in mammals. Physiological reviews, v. 87, n. 1, p. 1-28, 2007. WILSON, Jean D.; GRIFFIN, James E.; GEORGE, Fredrick W. Sexual differentiation: early hormone synthesis and action. Biology of reproduction, v. 22, n. 1, p. 9-17, 1980. -/- Emanuel Isaque Cordeiro da Silva Belo Jardim, 07 de Maio de 2020. (shrink)

The presence of the Church Fathers in Robert Grosseteste’s works has always been an object of interest for scholars. In a 1997 article, Robert Grosseteste and the Church Fathers, Neil Lewis has outlined the status quaestionis on the topic, and has made a few remarks on the peculiarities of Grosseteste’s works dating to different periods of his life. In fact, since the 1230s the presence of the Church Fathers was always prominent in the works of Grosseteste (who could read (...) Greek and draw directly from the Greek sources of the Patristic tradition), but in a way less and less exclusive. In this paper the author reconsiders this topic and makes further remarks on it, with particular regard for Grosseteste’s use of Augustine. (shrink)

Intuitively, moral responsibility requires conscious awareness of what one is doing, and why one is doing it, but what kind of awareness is at issue? Neil Levy argues that phenomenal consciousness—the qualitative feel of conscious sensations—is entirely unnecessary for moral responsibility. He claims that only access consciousness—the state in which information (e.g., from perception or memory) is available to an array of mental systems (e.g., such that an agent can deliberate and act upon that information)—is relevant to moral responsibility. (...) I argue that numerous ethical, epistemic, and neuroscientific considerations entail that the capacity for phenomenal consciousness is necessary for moral responsibility. I focus in particular on considerations inspired by P. F. Strawson, who puts a range of qualitative moral emotions—the reactive attitudes—front and center in the analysis of moral responsibility. (shrink)

As philosophical and scientific arguments for free will skepticism continue to gain traction, we are likely to see a fundamental shift in the way people think about free will and moral responsibility. Such shifts raise important practical and existential concerns: What if we came to disbelieve in free will? What would this mean for our interpersonal relationships, society, morality, meaning, and the law? What would it do to our standing as human beings? Would it cause nihilism and despair as some (...) maintain or would it rather have a humanizing effect on our practices and policies, freeing us from the negative effects of belief in free will? In this chapter we consider the practical implications of free will skepticism and argue that life without free will and basic desert moral responsibility would not be as destructive as many people believe. We argue that prospects of finding meaning in life or of sustaining good interpersonal relationships, for example, would not be threatened. On treatment of criminals, we argue that although retributivism and severe punishment, such as the death penalty, would be ruled out, preventive detention and rehabilitation programs would still be justified. While we will touch on all these issues below, our focus will be primarily on this last issue. -/- We begin in section I by considering two different routes to free will skepticism. The first denies the causal efficacy of the types of willing required for free will and receives its contemporary impetus from pioneering work in neuroscience by Benjamin Libet, Daniel Wegner, and John-Dylan Haynes. The second, which is more common in the philosophical literature, does not deny the causal efficacy of the will but instead claims that whether this causal efficacy is deterministic or indeterministic, it does not achieve the level of control to count as free will by the standards of the historical debate. We argue that while there are compelling objections to the first route—e.g., Al Mele (2009), Eddy Nahmias (2002, 2011), and Neil Levy (2005)—the second route to free will skepticism remains intact. In section II we argue that free will skepticism allows for a workable morality, and, rather than negatively impacting our personal relationships and meaning in life, may well improve our well-being and our relationships to others since it would tend to eradicate an often destructive form of moral anger. In section III we argue that free will skepticism allows for adequate ways of responding to criminal behavior—in particular, incapacitation, rehabilitation, and alternation of relevant social conditions—and that these methods are both morally justified and sufficient for good social policy. We present and defend our own preferred model for dealing with dangerous criminals, an incapacitation account built on the right to self-protection analogous to the justification for quarantine (see Pereboom 2001, 2013, 2014a; Caruso 2016a), and we respond to recent objections to it by Michael Corrado and John Lemos. (shrink)

As a senior physicist colleague and our friend, Robert N. Boyd, wrote in a journal (JCFA, Vol. 1,. 2, 2022), Our universe is but one page in a large book [4]. For example, things and Beings can travel between Universes, intentionally or unintentionally. In this short remark, we revisit and offer short remark to Neil’s ideas and trying to connect them with geometrization of musical chords as presented by D. Tymoczko and others, then to Escher staircase and then to (...) Jacob’s ladder which seems to point to possibility to interpret Jacob’s vision as described in the ancient book of Genesis as inter dimensional or heavenly staircase, e.g. an inter dimensional bridge between heaven and earth (see also classic book: Hofstadter, Godel, Escher, Bach). Jacob’s vision of angels going down to earth from that staircase has been depicted for instance in William Blake art etc. In our communication with others via physics literature and discussions etc, we came to several conclusions as follows: Firstly, possibility of quantum wormhole effect to mirror particle universe, which sometimes it is termed non-orientable wormhole. While such mirror particles effect have been more than 50 years predicted with the so-called parity violation (cf. Lee & Yang, 1950s), and that is called symmetry breaking. Secondly, a series of extended experiments on laser irradiated cold water may suggest possible transition from a phase of water to be at least partially fourth phase of water, which may be composed of crystalline water (see e.g. Gerald Pollack, and also Harold Aspden on liquid crystalline). If we can imagine laser cooling effect can be done in protracted time, then we can achieve a physical representation of Aspden’s liquid crystalline. Therefore, in subsequent article (Part II) we outlined simple model of such an effect of tunneling via quantum liquid crystalline Universe, which may likely be modeled with iced-water. It is interesting to remark here that certain experiments by Stockholm University scientists have shown that X-ray triggered water can exhibit properties just like liquid crystal (cf. PRL, 2020). That is why we consider it possible that there can be quantum phase transition where liquid water (comprised of iced cubes and water) can exhibit effects such as tunneling in quantum liquid crystalline Universe. Last but not least, we admit that what we outlined here is just an initial phase; and if you wish, perhaps we can call such experiments as “wormhole-at-lab” experiments (abbreviated: WHALE). (shrink)

This paper is based on the comments I gave to Alfred Mele regarding his original Zygote Argument during my presentation at a small workshop on manipulation arguments in Budapest back in 2012. After those comments, Mele changed the conclusion of his original Zygote Argument (OZA) from a positive, explanatory conclusion to a negative, non-explanatory conclusion--and, correspondingly, redefined 'incompatibilism' so that it would no longer refer in his work to the view that determinism precludes (undermines, eliminates, destroys, etc.) free will, but (...) refers narrowly to the perhaps spurious association claim that appears in the conclusion of the revised Zygote Argument (Mele 2013+). Yet, over the last decade, Mele has made no comment in print about the changes he made, the invalidity objection that led to them, nor to the fact that his revised Zygote Argument was originally presented by me as a (non-optimal) reaction to my invalidity objection to his original Zygote Argument. To my knowledge, Mele has only mentioned this 2015 paper once, at it was not in the context of understanding manipulation arguments; it was, rather, in the context of defending his revised, non-explanatory definition of 'incompatibilism' at the opening of Aspects of Agency (p. 6, n. 4). There, Mele singles out *just this 2015 paper* as a place where they'll find what Mele degrades as a type of nonstandard/nontraditional definition of 'incompatibilism' that he rejects. This is notable because Mele provides no empirical evidence that his preferred definition is standard, and most (including Lehrer, who coined the term) reject the negative, non-explanatory, association-based definition that Mele came to endorse in the aftermath of my invalidity objection to OZA. So, if Mele had a genuine concern about philosophers who use the term 'incompatibilism', then Mele could have--and should have--named almost any leading figure in free will for this purpose (since most--including Pereboom, Vihvelin, Haji, etc.) reject the non-explanatory definition that Mele-2013+ now endorses. Yet, for untold reasons, Mele isolated the working definition of 'incompatibilism' used in one paper by one unemployed junior researcher to use as his example--even though Neil Levy had used this same definition in previously published work (eg. Levy 2011). Moreover, if Mele were genuinely interested in helping his readers understand the ambiguity of terms like 'compatibilism' and 'incompatibilism' it is a mystery that he referenced a paper in which nothing of substance hung on the definitions given to these terms -- especially considering that he might have instead pointed them to my OTHER 2015 paper, "A Critique of Vihvelin's Three-Fold Classification" in which the MAIN AIM of the paper is to expose the difficulties facing anyone who wants to define the terms 'compatibilism' and 'incompatibilism' in a way that everyone will accept (including a critique of the negative, non-explanatory "incompossibilist" definition that Mele adopted after my objection to OZA). By all appearances, Mele's main aim in citing specifically THIS paper and none of my other work was to give readers the false impression that my working definition of 'incompatibilism' played some role in my charge that his argument is invalid (which it doesn't, given that the term doesn't appear in either the premises or conclusion of that argument). Mele adds to this unseemly rhetorical campaign in his book *Manipulation Agents* where he mentions an invalidity objection in the intro (p. 84) and then discusses that objection in the final lines of Chapter 5 of the book (p. 120-121). The invalidity objection discussed here is completely pedantic, has never been seriously raised in the primary literature (and was previously addressed in multiple places my multiple philosophers, including me), and has nothing whatever to do with my invalidity objection. In other words, Mele was content to discuss an invalidity objection that no one has ever had to an argument that is clearly valid while completely ignoring the ONLY substantive invalidity objection to his argument in print. This is unfortunate, because it has led to serious confusion --including the patently false description of my invalidity objection to OZA as an objection to the revised version of the Zygote Argument that Mele adopted in *response* my objection (e.g., Capes mistakenly claims "Mickelson (2015) contends that arguments like this [i.e. like the revised Zygote Argument] are invalid. But that’s because she defines “incompatibilism” differently than I’ve defined it here" in his "Manipulation Arguments and Direct Arguments" chapter in the 2023 Wiley-Blackwell Companion to Free Will; I did not say this, and the definition of 'incompatibilism' is irrelevant to my objection). In "The Zygote Argument Is Invalid--Now What?", I simply use the invalidity of the simple 2-premise Zygote Argument as a foil to make a series of more philosophically significant points (e.g. regarding the dialectical structure of the free-will debate, the role of best-explanation reasoning, and to develop the first-ever "master manipulation argument"). Mele has yet to address my reasons for calling attention to the non-trivial invalidity of his OZA or to any of my answers to the "Now What?" question in this paper, even though this question and my proposed answers to this question are the paper's main point. For those interested in a more recent discussion of how the logical and metaphilosophical observations made in this "Now What?" paper have helped to move the free-will debate forward, I suggest looking at the discussions of the "paradigm shift" in the free-will debate that helps to explain why the free-will debate has become mired in stalemates and empty verbal disputes that are found, for example, in my contributions to the Wiley-Blackwell Companion to Free Will (Intro and Chapter 4, 2023) and my paper "Free Will, Self-Creation, and the Paradox of Moral Luck" (2019). (shrink)

Free will skepticism maintains that what we do, and the way we are, is ultimately the result of factors beyond our control and because of this we are never morally responsible for our actions in the basic desert sense—the sense that would make us truly deserving of praise and blame. In recent years, a number of contemporary philosophers have advanced and defended versions of free will skepticism, including Derk Pereboom (2001, 2014), Galen Strawson (2010), Neil Levy (2011), Bruce Waller (...) (2011, 2015), and myself (Caruso 2012, 2013, forthcoming). Critics, however, often complain that adopting such views would have dire consequences for ourselves, society, morality, meaning, and the law. They fear, for instance, that relinquishing belief in free will and basic desert moral responsibility would leave us unable to adequately deal with criminal behavior, increase anti-social conduct, and undermine meaning in life. -/- In response, free will skeptics argue that life without free will and basic desert moral responsibility would not be as destructive as many people believe (see, e.g., Pereboom 2001, 2014; Waller 2011, 2015; Caruso 2016, forthcoming). According to optimistic skeptics, prospects of finding meaning in life or of sustaining good interpersonal relationships, for instance, would not be threatened. And although retributivism and severe punishment, such as the death penalty, would be ruled out, incapacitation and rehabilitation programs would still be justified (see Pereboom 2001, 2013, 2014; Levy 2012; Caruso 2016; Pereboom and Caruso, forthcoming). In this paper, I attempt to extend this general optimism about the practical implications of free will skepticism to the question of creativity. -/- In Section I, I spell out the question of creativity and explain why it’s relevant to the problem of free will. In Section II, I identify three different conceptions of creativity and explain the practical concerns critics have with free will skepticism. In Section III, I distinguish between three different conceptions of moral responsibility and argue that at least two of them are consistent with free will skepticism. I further contend that forward-looking accounts of moral responsibility, which are perfectly consistent with free will skepticism, can justify calling agents to account for immoral behavior as well as providing encouragement for creative activities since these are important for moral and creative formation and development. I conclude in Section IV by arguing that relinquishing belief in free will and basic desert would not mean the death of creativity or our sense of achievement since important and realistic conceptions of both remain in place. (shrink)

In “The Possibility of Epistemic Nudging” (2021), I address a phenomenon that is widely neglected in the current literature on nudges: intentional doxastic nudging, i.e. people’s intentional influence over other people’s beliefs, rather than over their choices. I argue that, at least in brute cases, nudging is not giving reasons, but rather bypasses reasoning altogether. More specifically, nudging utilizes psychological heuristics and the nudged person’s biases in smart ways. The goal of my paper is to defend the claim that nudging, (...) even when it bypasses reasoning, can result in justified beliefs and knowledge. As I argue, it takes two things to accomplish this goal: suitable meta-epistemological views and appropriate circumstances. If a broadly reliabilist account of justified beliefs and knowledge is correct, and if the relevant belief-forming methods are externally individuated in the right way, then nudging to knowledge is possible. If, in addition, the nudger is knowledgeable, epistemically benevolent and systematically effective, then nudging to knowledge will become reality. In their replies Neil Levy (2021) and Jonathan Matheson and Valerie Joly Chock (2021), put pressure on my argument from different angles. Levy thinks that a better case can be made for his view that nudging is giving testimonial reasons, and finds my objections to this view unconvincing. Matheson and Joly Chock, on the other hand, point out that acquiring knowledge through nudging (i.e. epistemic nudging) is compatible with evidentialism, even if nudging is not giving reasons. On their view, evidentialism provides an explanation of epistemic nudging that is superior to my own account, which, according to them, also suffers from a number of counterintuitive consequences. I am grateful to my critics for raising these concerns, because considering them deepens our perspective on the target phenomenon, and has made me think harder about the relevant epistemological issues. Nevertheless, I am convinced that my core claims can be defended against these criticisms. (shrink)

The present article was partly inspired by G. Pollack’s book, and also Dadoloff, Saxena & Jensen (2010). As a senior physicist colleague and our friend, Robert N. Boyd, wrote in a journal (JCFA, Vol. 1, No. 2, 2022), for example, things and Beings can travel between Universes, intentionally or unintentionally [4]. In this short remark, we revisit and offer short remark to Neil Boyd’s ideas and trying to connect them with geometry of musical chords as presented by D. Tymoczko (...) and others, then to Escherian staircase and then to Jacob’s ladder which seems to pointto possibility to interpret Jacob’s vision as described in the ancient book of Genesis as interdimensional staircase, e.g. an interdimensional bridge between heaven and earth (cf. classic book: Hofstadter, Godel, Escher, Bach). Jacob’s vision of angels going down to earth from that staircase has been depicted for instance in William Blake art etc. In our communication with others via physics literature and discussions etc, we came to several conclusions as follows: Firstly, possibility of wormhole effect to mirror particle universe, which sometimes it is termed non-orientable wormhole. While such mirror particles effect have been more than 50 years predicted with the so-called parity violation (cf. Lee & Yang, 1950s), and that is called symmetry breaking. Secondly, a series of extended experiments on laser irradiated cold water may suggest possible transition from a phase of water to be at least partially fourth phase of water, which may be composed of crystalline water (see e.g. Gerald Pollack, and also Harold Aspden on liquid crystalline). If we can imagine laser cooling effect can be done in protracted time, then we can achieve a physical representation of Aspden‘s liquid crystalline. Therefore, in this article we outline a series of simple experiments of laser irradiated iced-water along with beryl and selenite crystals in order to see possibility of such a quantum tunneling via quantum liquid crystalline Universe hypothesis, which may likely be modeled with iced-water. It is interesting to remark here that certain experiments by Stockholm University scientists have shown that X-ray triggered water can exhibit properties just like liquid crystal (cf. PRL, 2020). That is why we consider it possible that there can be quantum phase transition where liquid water (comprised of iced cubes and water) can exhibit effects such as tunneling in quantum liquid crystalline Universe. Last but not least, we admit that what we outlined here is just aninitial phase; and if you wish, perhaps we can call such experiments as “wormhole-at-lab” experiments (abbreviated: WHALE). (shrink)

COTENT -/- (April 2019) Why so many people (from so many countries/domains/on so many topics) have already plagiarized my ideas? (Gabriel Vacariu) -/- Some preliminary comments Introduction: The EDWs perspective in my article from 2005 and my book from 2008 -/- I. PHYSICS, COGNITIVE NEUROSCIENCE, PHILOSOPHY (‘REBORN DINOSAURS’) • (2016) Sean Carroll (California Institute of Technology, USA) • (2016) Frank Wilczek (Nobel Prize in Physics) • (2017-2019 - NEW March 2019) Carlo Rovelli in three books (2015, 2017) to my ideas (...) (2002-2008) + commentary February 2018! • (2016) Kastner + (2017) R. E. Kastner, Stuart Kauffman, Michael Epperson • (2017) Lee Smolin (2017) • (May 2018) ‘Thus spoke Zarathustra!’ - A fairy-tale with Eugen Ionesco and the Idiot about Nothingness -/- II. PHYSICS • (2011) Radu Ionicioiu (Physics, University of Bucharest, Romania) and Daniel R. Terno’s ideas (Physics, Macquarie University, Sydney • (2013) Côté B. Gilbert (Oontario, Canada) • (2015) Pikovski Igor, Zych Magdalena, Costa Fabio, and Brukner Časlav • (2015) Elisabetta Caffau (Center for Astronomy at the University of Heidelberg and the Paris Observatory) • (2015) Wolfram Schommers • (2015) Some astrophysicists • (2016) Dylan H. Mahler, Lee Rozema, Kent Fisher, Lydia Vermeyden, Kevin J. Resch, Howard M. Wiseman, and Aephraim Steinberg • (2016) Bill Poirier • (2016 or 2017) Adam Frank • (2017, 2017) Sebastian de Haro • (2017) Laura Condiotto • (2016) Hugo F. Alrøe and Egon Noe • (2017) Federico Zalamea • (2018) Unbelievable similarities between Peter J. Lewis’s ideas (2018) and my ideas (2002-2008) • (2018) Timothy Hollowood, ‘Classical from Quantum’ • (2018) Mario Hubert and Davide Romano, ‘The Wave-Function as a Multi-Field’ -/- III. COGNITIVE NEUROSCIENCE AND PHILOSOPHY OF MIND • (2011-2014) Did Georg Northoff (Psychoanalysis, Institute of Mental Health) plagiarize my ideas (2002-2008)? • (2011) Kalina Diego Cosmelli, Legrand Dorothée and Thompson Evan’s ideas (USA) • (2015) David Ludwig (Philosophy, University of Amsterdam) • (2016) Neil D. Theise (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA) and Kafatos C. Menas • David Bourget (2018) (or University of Western Ontario) + Chalmers • (2016) Dan Siegel (Mindsight Institute, USA) -/- IV. Philosophy (of science) • (2010) Alexey Alyushin (Moscow, Russia) • (2013 + 2017) Markus Gabriel (Bonn University) • (2013) Andrew Newman’s ideas (University of Nebraska, at Omaha, USA) • (2016) Tahko E. Tuomas (University of Helsinki, Finland) + Tahko E. Tuomas • (2017) Jani Hakkarainen (University of Tampere, Finland) + (2017) Markku Keinänen, Antti Keskinen & Jani Hakkarainen • (2017) Dean Rickles (HPS, Univ. of Sydney) • (2017) Did Dirk K. F. Meijer and Hans J. H. Geesink (University of Groningen, Netherlands) • (2018) Jason Winning’s ideas (2018) • (2018) David Mark Kovacs (Lecturer of philosophy at Tel Aviv University) -/- July 2018 • Oreste M. Fiocco • Baptiste Le Bihan (University of Geneva, forthcoming) • Antonella Mallozzi (The Graduate Center – CUNY, forthcoming in Synthese, penultimate draft) • Erik C. Banks (Wright State University, 2014) • Sami Pihlström (2009) • Katherin Koslicki’s ideas (2008) The Structure of Objects, Oxford University Press) and my ideas (2002-2005-2006) -/- November 2018 • Maurizio Ferraris (2014/2012) Manifesto of New Realism • Graham Harman (2017) : Object-Oriented Ontology: A New Theory of Everything (Penguin Books) -/- January 2019 • Philip Ball (2018) • Gerhard Grössing • Anne Sophie Meincke (November 2018) • Baptiste Le Bihana (University of Geneva) and James Read (Oxford Univ.) • Baptiste Le Bihan (University of Geneva) • Alexander Alexandrovich Antonov (2016) (Research Center of Information Technologies “TELAN Electronics”, Kiev, Ukraine): -/- February 2019 • James Barham (2019) • Giorgio Lando (2017) • (2018) Albrecht von M¨uller • Elias Zafiris • (2019) Flaminia Giacomini, Esteban Castro-Ruiz, & Časlav • (2019) Valia Allori, OUP (2019) • (2018) Paulo De Jesus Phenom Cogn Sci • (2016) TIMOTHY MORTON, For a Logic of Future Coexistence • (2017) Andrew Cooper, Two directions for teleology: naturalism and idealism, Synthese -/- March 2019 • (2019) Massimiliano Proietti,1 Alexander Pickston,1 Francesco Graffitti,1 Peter Barrow,1 Dmytro Kundys,1 Cyril Branciard,2 Martin Ringbauer,1, 3 and Alessandro Fedrizzi1: (2019) • (2015) Cˇaslav Brukner On the quantum measurement problem, at arXiv:1507.05255v1 [quant-ph] 19 Jul 2015 • (2015) Mateus Araújo, Cyril Branciard, Fabio Costa, Adrien Feix, Christina Giarmatzi, Časlav Brukner, Witnessing causal nonseparability, • (2008 + 2013) Giulio Chiribella,∗ Giacomo Mauro D’Ariano,† and Paolo Perinotti‡ QUIT Group, Dipartimento di Fisica “A. Volta” and INFM, via Bassi 6, 27100 Pavia, Italy§ (Dated: October 22, 2018): Transforming quantum operations: quantum supermaps arXiv:0804.0180v2 [quant-ph] (22 Oct 2008) + Giulio Chiribella,1, ∗ Giacomo Mauro D’Ariano,2, † Paolo Perinotti,2, ‡ and Benoit Valiron3, § (2013), Quantum computations without definite causal structure, at • (2013) Ognyan Oreshkov1;2, Fabio Costa1, Cˇ aslav Brukner1;3, Quantum correlations with no causal order, • (2018) Marcus Schmieke, Kränzlin, 17 July 2018 These articles are in this book: Reality and its Structure - Essays in Fundamentality, Ricki Bliss and Graham Priest (2018), -/- Gabriel Oak Rabin (2018) Grounding Orthodoxy and the Layered Conception Daniel Nolan (2018) Cosmic Loops Naomi Thompson (2018) Metaphysical Interdependence, Epistemic Coherentism, and Tuomas E. Tahko (2018) Holistic Explanation Fundamentality and Ontological Minimality Matteo Morganti (2018) The Structure of Physical Reality Beyond Foundationalism Nathan Wildman (2018) On Shaky Ground? Exploring the Contingent Fundamentality Thesis -/- April 2019 (2015) M. Ringbauer1;2, B. Du_us1;2, C. Branciard1;3, E. G. Cavalcanti4, A. G. White1;2 & A. Fedrizzi: “Measurements on the reality of the wavefunction” -/- June 2019 Timothy Morton (2013), Realist Magic: Objects, Ontology, Causality (2013) Open Humanities Press Ian Bogost, Alien Phenomenology or, What It’s Like to Be a Thing (Minneapolis: University of Minnesota Press, 2012), 1–34 “Ian Bogost thinks objects as units”: Unit Operations: An Approach to Videogame Criticism (Cambridge: MIT Press, 2008) in Timothy Morton 2013, Realist Magic: Objects, Ontology, Causality (2013) OPEN HUMANITIES PRESS (I have not read Bogost yet, but in Morton’s book, I found UNBELIEVABLE similarity between Bogost’s main ideas and my EDWs ideas!!) -/- [Obviously, there are other “specialists” that published UNBELIEVABLE similar ideas to my ideas but I have not discovered them yet…] -/- . (shrink)

COTENT -/- (April 2019) Why so many people (from so many countries/domains/on so many topics) have already plagiarized my ideas? (Gabriel Vacariu) -/- Some preliminary comments Introduction: The EDWs perspective in my article from 2005 and my book from 2008 -/- I. PHYSICS, COGNITIVE NEUROSCIENCE, PHILOSOPHY (‘REBORN DINOSAURS’) • (2016) Sean Carroll (California Institute of Technology, USA) • (2016) Frank Wilczek (Nobel Prize in Physics) • (2017-2019 - NEW March 2019) Carlo Rovelli in three books (2015, 2017) to my ideas (...) (2002-2008) + commentary February 2018! • (2016) Kastner + (2017) R. E. Kastner, Stuart Kauffman, Michael Epperson • (2017) Lee Smolin (2017) • (May 2018) ‘Thus spoke Zarathustra!’ - A fairy-tale with Eugen Ionesco and the Idiot about Nothingness -/- II. PHYSICS • (2011) Radu Ionicioiu (Physics, University of Bucharest, Romania) and Daniel R. Terno’s ideas (Physics, Macquarie University, Sydney • (2013) Côté B. Gilbert (Oontario, Canada) • (2015) Pikovski Igor, Zych Magdalena, Costa Fabio, and Brukner Časlav • (2015) Elisabetta Caffau (Center for Astronomy at the University of Heidelberg and the Paris Observatory) • (2015) Wolfram Schommers • (2015) Some astrophysicists • (2016) Dylan H. Mahler, Lee Rozema, Kent Fisher, Lydia Vermeyden, Kevin J. Resch, Howard M. Wiseman, and Aephraim Steinberg • (2016) Bill Poirier • (2016 or 2017) Adam Frank • (2017, 2017) Sebastian de Haro • (2017) Laura Condiotto • (2016) Hugo F. Alrøe and Egon Noe • (2017) Federico Zalamea • (2018) Unbelievable similarities between Peter J. Lewis’s ideas (2018) and my ideas (2002-2008) • (2018) Timothy Hollowood, ‘Classical from Quantum’ • (2018) Mario Hubert and Davide Romano, ‘The Wave-Function as a Multi-Field’ -/- III. COGNITIVE NEUROSCIENCE AND PHILOSOPHY OF MIND • (2011-2014) Did Georg Northoff (Psychoanalysis, Institute of Mental Health) plagiarize my ideas (2002-2008)? • (2011) Kalina Diego Cosmelli, Legrand Dorothée and Thompson Evan’s ideas (USA) • (2015) David Ludwig (Philosophy, University of Amsterdam) • (2016) Neil D. Theise (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA) and Kafatos C. Menas • David Bourget (2018) (or University of Western Ontario) + Chalmers • (2016) Dan Siegel (Mindsight Institute, USA) -/- IV. Philosophy (of science) • (2010) Alexey Alyushin (Moscow, Russia) • (2013 + 2017) Markus Gabriel (Bonn University) • (2013) Andrew Newman’s ideas (University of Nebraska, at Omaha, USA) • (2016) Tahko E. Tuomas (University of Helsinki, Finland) + Tahko E. Tuomas • (2017) Jani Hakkarainen (University of Tampere, Finland) + (2017) Markku Keinänen, Antti Keskinen & Jani Hakkarainen • (2017) Dean Rickles (HPS, Univ. of Sydney) • (2017) Did Dirk K. F. Meijer and Hans J. H. Geesink (University of Groningen, Netherlands) • (2018) Jason Winning’s ideas (2018) • (2018) David Mark Kovacs (Lecturer of philosophy at Tel Aviv University) -/- July 2018 • Oreste M. Fiocco • Baptiste Le Bihan (University of Geneva, forthcoming) • Antonella Mallozzi (The Graduate Center – CUNY, forthcoming in Synthese, penultimate draft) • Erik C. Banks (Wright State University, 2014) • Sami Pihlström (2009) • Katherin Koslicki’s ideas (2008) The Structure of Objects, Oxford University Press) and my ideas (2002-2005-2006) -/- November 2018 • Maurizio Ferraris (2014/2012) Manifesto of New Realism • Graham Harman (2017) : Object-Oriented Ontology: A New Theory of Everything (Penguin Books) -/- January 2019 • Philip Ball (2018) • Gerhard Grössing • Anne Sophie Meincke (November 2018) • Baptiste Le Bihana (University of Geneva) and James Read (Oxford Univ.) • Baptiste Le Bihan (University of Geneva) • Alexander Alexandrovich Antonov (2016) (Research Center of Information Technologies “TELAN Electronics”, Kiev, Ukraine): -/- February 2019 • James Barham (2019) • Giorgio Lando (2017) • (2018) Albrecht von M¨uller • Elias Zafiris • (2019) Flaminia Giacomini, Esteban Castro-Ruiz, & Časlav • (2019) Valia Allori, OUP (2019) • (2018) Paulo De Jesus Phenom Cogn Sci • (2016) TIMOTHY MORTON, For a Logic of Future Coexistence • (2017) Andrew Cooper, Two directions for teleology: naturalism and idealism, Synthese -/- March 2019 • (2019) Massimiliano Proietti,1 Alexander Pickston,1 Francesco Graffitti,1 Peter Barrow,1 Dmytro Kundys,1 Cyril Branciard,2 Martin Ringbauer,1, 3 and Alessandro Fedrizzi1: (2019) • (2015) Cˇaslav Brukner On the quantum measurement problem, at arXiv:1507.05255v1 [quant-ph] 19 Jul 2015 • (2015) Mateus Araújo, Cyril Branciard, Fabio Costa, Adrien Feix, Christina Giarmatzi, Časlav Brukner, Witnessing causal nonseparability, • (2008 + 2013) Giulio Chiribella,∗ Giacomo Mauro D’Ariano,† and Paolo Perinotti‡ QUIT Group, Dipartimento di Fisica “A. Volta” and INFM, via Bassi 6, 27100 Pavia, Italy§ (Dated: October 22, 2018): Transforming quantum operations: quantum supermaps arXiv:0804.0180v2 [quant-ph] (22 Oct 2008) + Giulio Chiribella,1, ∗ Giacomo Mauro D’Ariano,2, † Paolo Perinotti,2, ‡ and Benoit Valiron3, § (2013), Quantum computations without definite causal structure, at • (2013) Ognyan Oreshkov1;2, Fabio Costa1, Cˇ aslav Brukner1;3, Quantum correlations with no causal order, • (2018) Marcus Schmieke, Kränzlin, 17 July 2018 These articles are in this book: Reality and its Structure - Essays in Fundamentality, Ricki Bliss and Graham Priest (2018), -/- Gabriel Oak Rabin (2018) Grounding Orthodoxy and the Layered Conception Daniel Nolan (2018) Cosmic Loops Naomi Thompson (2018) Metaphysical Interdependence, Epistemic Coherentism, and Tuomas E. Tahko (2018) Holistic Explanation Fundamentality and Ontological Minimality Matteo Morganti (2018) The Structure of Physical Reality Beyond Foundationalism Nathan Wildman (2018) On Shaky Ground? Exploring the Contingent Fundamentality Thesis -/- April 2019 (2015) M. Ringbauer1;2, B. Du_us1;2, C. Branciard1;3, E. G. Cavalcanti4, A. G. White1;2 & A. Fedrizzi: “Measurements on the reality of the wavefunction” -/- June 2019 Timothy Morton (2013), Realist Magic: Objects, Ontology, Causality (2013) Open Humanities Press Ian Bogost, Alien Phenomenology or, What It’s Like to Be a Thing (Minneapolis: University of Minnesota Press, 2012), 1–34 “Ian Bogost thinks objects as units”: Unit Operations: An Approach to Videogame Criticism (Cambridge: MIT Press, 2008) in Timothy Morton 2013, Realist Magic: Objects, Ontology, Causality (2013) OPEN HUMANITIES PRESS (I have not read Bogost yet, but in Morton’s book, I found UNBELIEVABLE similarity between Bogost’s main ideas and my EDWs ideas!!) -/- [Obviously, there are other “specialists” that published UNBELIEVABLE similar ideas to my ideas but I have not discovered them yet…] -/- . (shrink)

In this eleventh book of scilogs – called in-turns and out-turns –, one may find new and old questions and solutions, referring mostly to topics on Neutrosophy, but also Multispace, with miscellaneous addition of topics on Physics, Mathematics, or Sociology – email messages to research colleagues, or replies, notes about authors, articles, or books, spontaneous ideas, and so on. -/- Exchanging ideas with Prem Kumar Singh, Feng Liu, Nicolae Bălașa, Jimmy Quellet, Minodora Rușchița, Frank Gelli, A. R. Vătuiu, Victor Christianto, (...) Vladimir I. Rogozhin, Robert Neil Boyd, Akira Kanda, Stefan Spaarmann, Oliver Consa, Yabin Shao, Junle Zhuo, Nivetha Martin, Said Broumi, Jean Dezert, Erick González, Tomasz Witczak, B. De Baets, I. Couso, D. Dubois, L. Good, Mihaela Colhon, Atiqe Ur Rahman, Muhammad Saeed, Muhammad Ihsan, Edeline Nancy, Shawkat Alkhazaleh, Shazia Rana, Vasantha Kandasamy, Santanu Acharjee, Mohamed Al-Shmrani, Parimala Manie, Mehmet Unver, Murat Olgun, Adel Aleidhri, Akira Kanda, Ilanthenral Kandasamy, Mircea Zărnescu, R. Tayebi Khorami, Arsham Borumand Saeid, Maisam Jdid, M. Abobala, Riad Hamido, Rafael Rojas, Esmaeil Zarei, Faisal Khan, Rouzbeh Abbassi, Adel Al-Odhari, Henry Garrett, Ackbar Rezaei, Saeid Jafari, Karthika Muthusamy, Harish Garg, Huda E. Khalid, Gonca D. Güngör, Muslim A. Noah Zainal, Fakhry Asad Agusfrianto, Madeleine Al-Tahan, Mariam Hariri, Yudi Mahatma, Masoud Ghods, Marco Brigliadori, Luis Enrique Aponte Pérez, Amr Mohammed, M. Aslam (in order of reference in the book). (shrink)

In this ninth book of scilogs collected from my nest of ideas, one may find new and old questions and solutions, – in email messages to research colleagues, or replies, and personal notes, some handwritten on the planes to, and from international conferences, about topics on Neutrosophy and its applications, such as: Neutrosophic Bipolar Set, Linguistic Neutrosophic Set, Neutrosophic Resonance Frequency, n-ary HyperAlgebra, n-ary NeutroHyperAlgebra, n-ary AntiHyperAlgebra, Plithogenic Crisp Graph, Plithogenic Fuzzy Graph, Plithogenic Intuitionistic Fuzzy Graph, Plithogenic Neutrosophic Graph, Plithogenic (...) Real Number Graph, Plithogenic Complex Number Graph, Plithogenic Neutrosophic Number Graph, and many more. -/- Exchanging ideas with: Tareq Al-Shami, Riad Khidr Al-hamido, Mohammad Akram, B. De Baets, Robert Neil Boyd, Said Broumi, Terman Frometa-Castillo, Yilmaz Ceven, D. Dubois, Harish Garg, L. Godo, Erik Gonzalez, Yanhui Guo, Mohammad Hamidi, E. Hüllermeier, W. B. Vasantha Kandasamy, Mary Jansi, Nivetha Martin, Mani Parimala, Akbar Rezaei, Bouzina Salah, Christy Vincent, Jun Ye.‬‬‬. (shrink)

COTENT -/- (second April 2019) Why so many people (from so many countries/domains/on so many topics) have already plagiarized my ideas? (Gabriel Vacariu) -/- Some preliminary comments Introduction: The EDWs perspective in my article from 2005 and my book from 2008 -/- I. PHYSICS, COGNITIVE NEUROSCIENCE, PHILOSOPHY (‘REBORN DINOSAURS’ ) • (2016) Did Sean Carroll’s ideas (California Institute of Technology, USA) plagiarize my ideas (2002-2010) (within the EDWs framework)? • (2016) Frank Wilczek’s ideas (Nobel Prize in Physics) (Philosophy of Mind (...) and Quantum Mechanics) • (2017-2019 - NEW March 2019) Carlo Rovelli’s ideas (Italy) in three books (2015, 2017) to my ideas (2002-2008) + commentary February 2018! • (2016) Kastner + (2017) R. E. Kastner, Stuart Kauffman, Michael Epperson • (2017) A trick: Lee Smolin’s ideas (2017) and my ideas (2002-2008) • (May 2018) ‘Thus spoke Zarathustra!’ - A fairy-tale with Eugen Ionesco and the Idiot about Nothingness -/- II. PHYSICS • (2011) Radu Ionicioiu (Physics, University of Bucharest, Romania) and Daniel R. Terno (Physics, Macquarie University, Sydney, Australia) • (2013) Côté B. Gilbert (Oontario, Canada) • (2015) Pikovski Igor, Zych Magdalena, Costa Fabio, and Brukner Časlav’s ideas and my ideas (2006-2008) (Quantum Mechanics) • (2015) Elisabetta Caffau’s ideas (Center for Astronomy at the University of Heidelberg and the Paris Observatory) and my ideas (2011, 2014) • (2015) Did Wolfram Schommers (University of Texas at Arlington, USA & Karlsruhe Institute of Technology, Germany) (Physics) • (2015) "Dark Matter May be 'Another Dimension' - Or Even a Major Galactic Transport System" January 22, 2015 • (2016) Dylan H. Mahler, Lee Rozema, Kent Fisher, Lydia Vermeyden, Kevin J. Resch, Howard M. Wiseman, and Aephraim Steinberg’s ideas (USA) • (2016) Bill Poirier’s ‘Many Interacting Worlds’ (Quantum Mechanics) • (2016 or Adam Frank’s ideas (University of Rochester in New York , USA) • (2017, 2017) Did Sebastian de Haro (HPS, Cambridge, UK) plagiarize my ideas (2002-2008) • (2017) Laura Condiotto’s ideas and my ideas (2002-2008) • (2016) Hugo F. Alrøe and Egon Noe’s (Department of Agroecology, Aarhus University, Denmark) ideas (USA) • (2017) Federico Zalamea’s ideas and my ideas • (2018) Peter J. Lewis’s ideas (2018) and my ideas (2002-2008) • (2018) Timothy Hollowood, ‘Classical from Quantum’, [arXiv:1803.04700v1 [quant-ph] 13 March 2018] • (2018) Mario Hubert and Davide Romano, ‘The Wave-Function as a Multi-Field’ -/- III. COGNITIVE NEUROSCIENCE AND PHILOSOPHY OF MIND • (2011-2014) Did Georg Northoff (Psychoanalysis, Institute of Mental Health) plagiarize my ideas (2002-2008)? • (2011) Kalina Diego Cosmelli, Legrand Dorothée and Thompson Evan’s ideas (USA) and my ideas (Cognitive Neuroscience) • (2015) Did David Ludwig (Philosophy, University of Amsterdam) plagiarize many of my ideas? (Philosophy (of Mind) • (2016) Neil D. Theise (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA) and Kafatos C. Menas (Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA) • David Bourget (2018) (Director, Centre for Digital Philosophy, Western University (or University of Western Ontario) + Chalmers • (2016) Dan Siegel’s ideas (Mindsight Institute, USA) -/- IV. Philosophy (of science) • (2010) Alexey Alyushin (Moscow, Russia) • (2013 + 2017) Did Markus Gabriel (Bonn University) • (2013) Andrew Newman’s ideas (University of Nebraska, at Omaha, USA) • (2016) Did Tahko E. Tuomas (University of Helsinki, Finland) plagiarize my ideas? + Tahko E. Tuomas (‘The Epistemology of Essence’) • (2017) Jani Hakkarainen (University of Tampere, Finland) + (2017) Markku Keinänen, Antti Keskinen & Jani Hakkarainen • (2017) Dean Rickles’s ideas (HPS, Univ. of Sydney) • (2017) Did Dirk K. F. Meijer and Hans J. H. Geesink (University of Groningen, Netherlands • (2018) Jason Winning’s ideas (2018) • (2018) David Mark Kovacs (Lecturer of philosophy at Tel Aviv University) -/- Conclusion Bibliography -/- July 2018 • Oreste M. Fiocco • Baptiste Le Bihan (University of Geneva, forthcoming) • Antonella Mallozzi (The Graduate Center – CUNY, forthcoming in Synthese, penultimate draft) • Erik C. Banks (Wright State University, 2014) • Sami Pihlström (2009) • Katherin Koslicki’s ideas (2008) -/- November 2018 • Maurizio Ferraris (2014/2012) Manifesto of New Realism • Graham Harman (2017) : Object-Oriented Ontology: -/- January 2019 • Philip Ball (2018): “Why everything you thought you knew about quantum physics is different” • Gerhard Grössing “Vacuum landscaping: cause of nonlocal influences without signaling” • Anne Sophie Meincke (November 2018) The Disappearance of Change (IJPS) • Baptiste Le Bihana (University of Geneva) and James Read (Oxford Univ.) “Duality and Ontology” • Baptiste Le Bihan (University of Geneva): “Space Emergence in Contemporary Physics: • Alexander Alexandrovich Antonov (2016) -/- February 2019 • James Barham (2019): “The Reality of Purpose and the Reform of Naturalism” • Giorgio Lando (2017) Mereology - A Philosophical Introduction, Bloomsbury Academic • (2018) Albrecht von M¨uller • Elias Zafiris, Concept and Formalization of Constellatory Self-Unfolding • (2019) Flaminia Giacomini, Esteban Castro-Ruiz, & Časlav Brukner • (2019) Valia Allori, “Scientific Realism without the Wave-Function: An Example of Naturalized Quantum Metaphysics” • (2018) Paulo De Jesus “Thinking through enactive agency: • (2016) TIMOTHY MORTON, For a Logic of Future Coexistence, (Columbia University Press) • (2017) Andrew Cooper, Two directions for teleology: -/- March 2019 • (2019) Massimiliano Proietti,1 Alexander Pickston,1 Francesco Graffitti,1 Peter Barrow,1 Dmytro Kundys,1 Cyril Branciard,2 Martin Ringbauer,1, 3 and Alessandro Fedrizzi1: (2019) “Experimental rejection of observer-independence in the quantum world” • (2015) Cˇaslav Brukner On the quantum measurement problem, • (2015) Mateus Araújo, Cyril Branciard, Fabio Costa, Adrien Feix, Christina Giarmatzi, Časlav Brukner, Witnessing causal nonseparability, • (2008 + 2013) Giulio Chiribella,∗ Giacomo Mauro D’Ariano,† and Paolo Perinotti‡ QUIT Group, Dipartimento di Fisica “A. Volta” and INFM, via Bassi 6, 27100 Pavia, Italy§ (Dated: October 22, 2018): Transforming quantum operations: quantum supermaps (22 Oct 2008) + Giulio Chiribella,1, ∗ Giacomo Mauro D’Ariano,2, † Paolo Perinotti,2, ‡ and Benoit Valiron3, § (2013), Quantum computations without definite causal structure, • (2013) Ognyan Oreshkov1;2, Fabio Costa1, Cˇ aslav Brukner1;3, Quantum correlations • (2018) Marcus Schmieke, Kränzlin, 17 July 2018, “Orthogonal Complementarity -/- April 2019 These articles are in this book: Reality and its Structure - Essays in Fundamentality, Ricki Bliss and Graham Priest (2018), Oxford Univ Press -/- Gabriel Oak Rabin (2018) Grounding Orthodoxy and the Layered Conception Daniel Nolan (2018) Cosmic Loops Naomi Thompson (2018) Metaphysical Interdependence, Epistemic Coherentism, and Tuomas E. Tahko (2018) Holistic Explanation Fundamentality and Ontological Minimality Matteo Morganti (2018) The Structure of Physical Reality Beyond Foundationalism Nathan Wildman (2018) On Shaky Ground? Exploring the Contingent Fundamentality Thesis -/- (2015) M. Ringbauer, B. Duffus, C. Branciard1;3, E. G. Cavalcanti4, A. G. White1;2 & A. Fedrizzi: “Measurements on the reality of the wavefunction” . (shrink)

The following is a transcript of the interview I (Yasuko Kitano) conducted with Neil Levy (The Centre for Applied Philosophy and Public Ethics, CAPPE) on the 23rd in July 2009, while he was in Tokyo to give a series of lectures on neuroethics at The University of Tokyo Center for Philosophy. I edited his words for publication with his approval.

Zero provides a challenge for philosophers of mathematics with realist inclinations. On the one hand it is a bona fide cardinal number, yet on the other it is linked to ideas of nothingness and non-being. This paper provides an analysis of the epistemology and metaphysics of zero. We develop several constraints and then argue that a satisfactory account of zero can be obtained by integrating an account of numbers as properties of collections, work on the philosophy of absences, and recent (...) work in numerical cognition and ontogenetic studies. (shrink)

Awarding rights to rivers, forests, and other environmental entities (EEs) is a new and increasingly popular approach to environmental protection. The distinctive feature of such rights of nature (RoN) legislation is that direct duties are owed to the EEs. This paper presents a novel rebuttal of the strongest argument against RoN: the no interest argument. The crux of this argument is that because EEs are not sentient, they cannot possess the kinds of interests necessary to ground direct duties. Therefore, they (...) cannot be legitimate rights-bearers. After considering and rejecting standard responses to this argument, the paper challenges its fundamental assumption: that rights-correlative duties must be grounded in the interests of the rights-bearer. The paper then presents the RoN critic with a dilemma. The critic must either accept that EEs are legitimate rights-bearers, or delegitimise many well-established rights-bearers along with EEs. Either way, the no interest argument loses its force. (shrink)

This essay presents an ideal for modern Western romantic love.The basic ideas are the following: people want to form a distinctive sort of plural subject with another, what Nozick has called a "We", they want to be loved for properties of certain kinds, and they want this love to establish and sustain a special sort of commitment to them over time.

Much of the discussion of set-theoretic independence, and whether or not we could legitimately expand our foundational theory, concerns how we could possibly come to know the truth value of independent sentences. This paper pursues a slightly different tack, examining how we are ignorant of issues surrounding their truth. We argue that a study of how we are ignorant reveals a need for an understanding of set-theoretic explanation and motivates a pluralism concerning the adoption of foundational theory.

In this paper I draw apart two different contexts of Freirean pedagogical practice that I label interactional and institutional. The interactional refers to the immediate learning environment with relation to the interaction between the students and the teacher. In contrast, the institutional refers to how the institutions of education are managed, constructed, and organised and how they relate to the individuals those institutions are composed of. I begin by presenting a brief overview of Freire’s argument in favour of a revolutionary (...) pedagogy. I then highlight how this project is represented at both interactional and institutional levels with a particular focus upon the practice of the revolutionary leaders and their role in the development of the humanisation of the oppressed. In presenting the interactional and institutional elements of Freire’s pedagogy separately the tension between the individual and the state is made plain and the limitations of his politico-educational project are drawn out. I argue that due to an inconsistent application of the relationship between means and ends in Freire’s politico-educational project an incoherence between the interactional and institutional levels of education is highlighted. In responding to this limitation of Freire’s politico-educational project with a thoroughly interconnected relationship of means and ends I show that there remains a necessary conflict between the interests of the individual and the state. As a result of this a door is opened for the development of an argument in favour of the disestablishment of education and state from a Freirean perspective. (shrink)

The rightness and wrongness of actions fits on a continuous scale. This fits the way we evaluate actions chosen among a diverse range of options, even though English speakers don’t use the words “righter” and “wronger”. I outline and defend a version of scalar consequentialism, according to which rightness is a matter of degree, determined by how good the consequences are. Linguistic resources are available to let us truly describe actions simply as right. Some deontological theories face problems in accounting (...) for degrees of rightness, as they don't invoke continuous parameters among the right-making features of action. (shrink)

In this paper we sketch a new version of aesthetic expressivism. We argue that one advantage of this view is that it explains various putative norms on the formation and revision of aesthetic judgement. We begin by setting out our proposed explananda and a sense in which they can be understood as governing the correct response to putative higher-order evidence in aesthetics. We then summarise some existing discussions of expressivist attempts to explain these norms, and objections raised to them. This (...) will allow us to identify the pitfalls that a good expressivist explanation needs to avoid. Finally, we sketch our preferred version of aesthetic expressivism which includes as a crucial part a hypothesis concerning the distinctive expressive function of aesthetic practice. We then consider how this theory can explain the putative aesthetic norms whilst avoiding the previous objections. (shrink)

A central area of current philosophical debate in the foundations of mathematics concerns whether or not there is a single, maximal, universe of set theory. Universists maintain that there is such a universe, while Multiversists argue that there are many universes, no one of which is ontologically privileged. Often forcing constructions that add subsets to models are cited as evidence in favour of the latter. This paper informs this debate by analysing ways the Universist might interpret this discourse that seems (...) to necessitate the addition of subsets to V. We argue that despite the prima facie incoherence of such talk for the Universist, she nonetheless has reason to try and provide interpretation of this discourse. We analyse extant interpretations of such talk, and analyse various tradeoffs in naturality that might be made. We conclude that the Universist has promising options for interpreting different forcing constructions. (shrink)

A number of concerns have been raised about the possible future use of pharmaceuticals designed to enhance cognitive, affective, and motivational processes, particularly where the aim is to produce morally better decisions or behavior. In this article, we draw attention to what is arguably a more worrying possibility: that pharmaceuticals currently in widespread therapeutic use are already having unintended effects on these processes, and thus on moral decision making and morally significant behavior. We review current evidence on the moral effects (...) of three widely used drugs or drug types: propranolol, selective serotonin reuptake inhibitors, and drugs that effect oxytocin physiology. This evidence suggests that the alterations to moral decision making and behavior caused by these agents may have important and difficult-to-evaluate consequences, at least at the population level. We argue that the moral effects of these and other widely used pharmaceuticals warrant further empirical research and ethical analysis. (shrink)

Many philosophers argue that the face-value of moral practice provides presumptive support to moral realism. This paper analyses such arguments into three steps. (1) Moral practice has a certain face-value, (2) only realism can vindicate this face value, and (3) the face-value needs vindicating. Two potential problems with such arguments are discussed. The first is taking the relevant face-value to involve explicitly realist commitments; the second is underestimating the power of non-realist strategies to vindicate that face-value. Case studies of each (...) of these errors are presented, drawn from the writings of Shafer-Landau, Brink and McNaughton, and from recent work in experimental metaethics. The paper then considers weak presumptive arguments, according to which both realist and non-realist vindications of moral practice are possible, but the realist vindications are more natural. It is argued that there is no sense of ‘natural’ available that can make these arguments work. The conclusion is that all extant presumptive arguments for moral realism fail. (shrink)

This essay defends a strong version of the Humean theory of motivation on which desire is necessary both for motivation and for reasoning that changes our desires. Those who hold that moral judgments are beliefs with intrinsic motivational force need to oppose this view, and many of them have proposed counterexamples to it. Using a novel account of desire, this essay handles the proposed counterexamples in a way that shows the superiority of the Humean theory. The essay addresses the classic (...) objection that the Humean theory cannot explain the feeling of obligation, Stephen Darwall's example of motivationally potent reasoning that is not based on preexisting desires, Thomas Scanlon's criticism that the Humean theory fails to account for the structure and phenomenology of deliberation, and the phenomenon of akrasia as discussed by John Searle. In each case a Humean account explains the data at least as thoroughly as opposing views can, while fitting within a simpler total account of how we deliberate and act. (shrink)

Philosophers from Hart to Lewis, Johnston and Bennett have expressed various degrees of reservation concerning the doctrine of double effect. A common concern is that, with regard to many activities that double effect is traditionally thought to prohibit, what might at first look to be a directly intended bad effect is really, on closer examination, a directly intended neutral effect that is closely connected to a foreseen bad effect. This essay examines the extent to which the commonsense concept of intention (...) supports a reasonably consistent and coherent application of double effect. Two important conclusions are these: (1) a number of traditionally proscribed activities involve a kind of “targeting” of innocents that can be taken to exhibit a direct intention to harm them; (2) a direct intention to harm need not involve a desire to harm in any ordinary sense of the latter expression. (shrink)

In this paper I argue that the explanationist argument in favour of moral realism fails. According to this argument, the ability of putative moral properties to feature in good explanations provides strong evidence for, or entails, the metaphysical claims of moral realism. Some have rejected this argument by denying that moral explanations are ever good explanations. My criticism is different. I argue that even if we accept that moral explanations are (sometimes) good explanations the metaphysical claims of realism do not (...) follow. (shrink)

Recent work in neuroimaging suggests that some patients diagnosed as being in the persistent vegetative state are actually conscious. In this paper, we critically examine this new evidence. We argue that though it remains open to alternative interpretations, it strongly suggests the presence of consciousness in some patients. However, we argue that its ethical significance is less than many people seem to think. There are several different kinds of consciousness, and though all kinds of consciousness have some ethical significance, different (...) kinds underwrite different kinds of moral value. Demonstrating that patients have phenomenal consciousness — conscious states with some kind of qualitative feel to them — shows that they are moral patients, whose welfare must be taken into consideration. But only if they are subjects of a sophisticated kind of access consciousness — where access consciousness entails global availability of information to cognitive systems — are they persons, in the technical sense of the word employed by philosophers. In this sense, being a person is having the full moral status of ordinary human beings. We call for further research which might settle whether patients who manifest signs of consciousness possess the sophisticated kind of access consciousness required for personhood. (shrink)

Multiverse Views in set theory advocate the claim that there are many universes of sets, no-one of which is canonical, and have risen to prominence over the last few years. One motivating factor is that such positions are often argued to account very elegantly for technical practice. While there is much discussion of the technical aspects of these views, in this paper I analyse a radical form of Multiversism on largely philosophical grounds. Of particular importance will be an account of (...) reference on the Multiversist conception, and the relativism that it implies. I argue that analysis of this central issue in the Philosophy of Mathematics indicates that Radical Multiversism must be algebraic, and cannot be viewed as an attempt to provide an account of reference without a softening of the position. (shrink)

This paper elaborates and defends an expressivist account of the claims of mind-independence embedded in ordinary moral thought. In response to objections from Zangwill and Jenkins it is argued that the expressivist 'internal reading' of such claims is compatible with their conceptual status and that the only 'external reading' available doesn't commit expressivisists to any sort of subjectivism. In the process a 'commitment-theoretic' account of the semantics of conditionals and negations is defended.

In the contemporary philosophy of set theory, discussion of new axioms that purport to resolve independence necessitates an explanation of how they come to be justified. Ordinarily, justification is divided into two broad kinds: intrinsic justification relates to how `intuitively plausible' an axiom is, whereas extrinsic justification supports an axiom by identifying certain `desirable' consequences. This paper puts pressure on how this distinction is formulated and construed. In particular, we argue that the distinction as often presented is neither well-demarcated nor (...) sufficiently precise. Instead, we suggest that the process of justification in set theory should not be thought of as neatly divisible in this way, but should rather be understood as a conceptually indivisible notion linked to the goal of explanation. (shrink)

What is posthumanism and why does it matter? This book offers an introduction to the ways in which humanism's belief in the natural supremacy of the Family of Man has been called into question at different moments and from different theoretical positions. What is the relationship between posthumanism and technology? Can posthumanism have a politics—postcolonial or feminist? Are postmodernism and poststructuralism posthumanist? What happens when critical theory meets Hollywood cinema? What links posthumanism to science fiction. Posthumanism addresses these and other (...) questions in an attempt to come to terms with one of the most pressing issues facing contemporary society. (shrink)

We explain and explore class-theoretic potentialism—the view that one can always individuate more classes over a set-theoretic universe. We examine some motivations for class-theoretic potentialism, before proving some results concerning the relevant potentialist systems (in particular exhibiting failures of the $\mathsf {.2}$ and $\mathsf {.3}$ axioms). We then discuss the significance of these results for the different kinds of class-theoretic potentialists.

Actions performed in a state of automatism are not subject to moral evaluation, while automatic actions often are. Is the asymmetry between automatistic and automatic agency justified? In order to answer this question we need a model or moral accountability that does justice to our intuitions about a range of modes of agency, both pathological and non-pathological. Our aim in this paper is to lay the foundations for such an account.

I argue that one intends that ϕ if one has a desire that ϕ and an appropriately related means-end belief. Opponents, including Setiya and Bratman, charge that this view can't explain three things. First, intentional action is accompanied by knowledge of what we are doing. Second, we can choose our reasons for action. Third, forming an intention settles a deliberative question about what to do, disposing us to cease deliberating about it. I show how the desire- belief view can explain (...) why these phenomena occur when they occur, and why they don't when they don't. (shrink)

This paper argues that qualia share their physical correlates' locations. The first premise comes from the theory of relativity: If something shares a time with a physical event in all reference frames, it shares that physical event’s location. The second premise is that qualia share times with their correlates in all reference frames. Having qualia and correlates share locations makes relations between them easier to explain, improving both physicalist and dualist theories.

Let's suppose you think that there are no uncountable sets. Have you adopted a restrictive position? It is certainly tempting to say yes---you've prohibited the existence of certain kinds of large set. This paper argues that this intuition can be challenged. Instead, I argue that there are some considerations based on a formal notion of restrictiveness which suggest that it is restrictive to hold that there are uncountable sets.

Propositionalism is the view that the contents of intentional attitudes have a propositional structure. Objectualism opposes propositionalism in allowing the contents of these attitudes to be ordinary objects or properties. Philosophers including Talbot Brewer, Paul Thagard, Michelle Montague, and Alex Grzankowski attack propositionalism about such attitudes as desire, liking, and fearing. This article defends propositionalism, mainly on grounds that it better supports psychological explanations.